Carica papaya ameliorates Nissl Bodies, Grey Matter distortion in Streptozotocin Induced Cerebral Hyperglycemia

Abstract

Carica papaya have been reported for treatment of numerous diseases such as glandular tumors, blood pressure, dyspepsia, constipation, amenorrhea, stomach ulcer, malaria, Dengue fever, cancer and Diabetes Mellitus. Diabetes is characterized by hyperglycemia. This study evaluated the ameliorating effect of Carica Papaya leave extract on distorted histoarchitecture of cerebrum in hyperglycemic states. The experimental animals (20 Wistar rats) weighed 100-130g were divided randomly into Group 1 which consisted five (5) normoglycemic rats administered with intraperitoneal (i.p.) 2m/ls of distilled water, Group 2 which consisted five (5) hyperglycemic rats administered i.p. streptozotocin (STZ) at 100mg/kg with 2mls of i.p. distilled water, Group 3 made up of five (5) hyperglycemic rats treated i.p. STZ at 100mg/kg with 800mg/kg of oral Carica papaya leave extract and Group 4 were five (5) normoglycemic rats treated with 800mg/kg of oral Carica papaya leaves extract. Treatment was carried out for 21 days. The cerebrum of hyperglycemic group under microscopic examination showed disorganized and distorted nissle bodies, grey and white matters. Studied hyperglycemic group treated with 800mg/kg of Carica papaya leaves showed marked amelioration of the examined parameters. Conclusively, the study showed Carica papaya leaves are of possible ameliorative importance in managing integrity of cerebral cell structures caused by diabetes- induced cell disruptions.